Nicotine Inhalers
A theoretical benefit of the Nicotine Inhaler is that it can provide
smokers the comfort of a cigarette ritual with hand-to-mouth nicotine
delivery during cessation, although the importance of these behavioral
features in smoking cessation is unknown.
The Nicotine Inhaler is a plastic rod that looks like a cigarette
holder and contains a replaceable cartridge of nicotine-impregnated
cotton that delivers up to 4 mg of nicotine vapor (from a 10 mg
"plug") when puffed. Although called an inhaler, the device is actually
a puffing apparatus meant to deliver the majority of its nicotine
to the mouth and posterior pharynx for mucosal absorption, similar
to nicotine gum; no significant amount
of nicotine actually reaches the lungs. Thus, the pharmacokinetics
of the Inhaler are similar to nicotine gum; of the 4 mg that may
be delivered orally, only about 2 mg are absorbed after about 80
puffs over 20 minutes. Peak plasma concentrations occur within 15
minutes of the end of "inhalation" and are lower than occur in smoking.
As with other forms of NRT, the Inhaler
consistently doubles quit-rates compared to placebo.
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